Milano was born in Brooklyn, New York on December 19, 1972 to a fashion designer mother and a film music editor father. She unexpectedly took on acting at the age of 7 when her babysitter took her to an audition for the musical Annie, and she landed a part of an orphan. She spent the next 18 months of her life traveling with the show and knew this is the career she wanted for the rest of her life.
A few years later, at the age of 12, Milano was offered a role in the hit sitcom Who’s the Boss?, playing star Tony Danza‘s young daughter. She spent the entirety of her adolescence on the show, turning her into a 1980s teen icon. To keep herself from being typecast as a wholesome teenager, she began to take more daring and risqué roles.
Breaking back into the scene again as an adult, Milano’s next big leading role was in the cult TV hit, Charmed, a show about modern-day witches. Though there were clashes between Milano and her co-star, Shannen Doherty, who left the show after the third season, Charmed lasted for eight seasons and attracted an entirely new fan base for Milano.
An avid baseball fan since childhood, she published a book about her love of baseball called Safe at Home: Confessions of a Baseball Fanatic in 2010 and regularly writes a blog on Major League Baseball’s website about the Los Angeles Dodgers. After noticing that most sports teams did not offer apparel that was specifically tailored for women, Milano pitched a female-targeted teamwear line to the MLB. Soon she had her own line called “Touch” which has now expanded to other sports than just baseball.
After a life-changing trip she took to South Africa in the early 2000s, Milano became an ambassador for both UNICEF and the Global Network for Neglected Tropical Diseases, and she often encourages her fans to donate to these charitable causes and others. She also appeared in an advertisement for PETA and helped film a viral Funny or Die sketch to bring attention to the Syrian civil war.
Though she has had much success in the entertainment industry, Milano values her philanthropic work as her greatest accomplishment saying, “I think I’m most proud to be an ambassador for UNICEF. That’s probably the work I’m most proud of. It’s very humbling and wonderful.”